2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-12778S
    N-Demethyl Ivabradine-d6 hydrochloride
    		≥98.0%
    N-Demethyl Ivabradine-d6 (hydrochloride) is the deuterium labeled N-Demethyl Ivabradine, which is a metabolite of Ivabradine.
    N-Demethyl Ivabradine-d<sub>6</sub> hydrochloride
  • HY-122439
    Lovastatin acid
    Lovastatin acid (Mevinolinic acid), an active metabolite of Lovastatin, is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM.
    Lovastatin acid
  • HY-103687
    Abiraterone metabolite 1
    		99.59%
    Abiraterone metabolite 1 is a 5β-reduced metabolite of abiraterone. Abiraterone, a steroidal agent, inhibits CYP17A1, blocks androgen synthesis and prolongs survival in prostate cancer.
    Abiraterone metabolite 1
  • HY-12769
    Mebeverine acid
    		99.70%
    Mebeverine acid (Mebeverine metabolite Mebeverine acid) is a secondary metabolite of Mebeverine. Mebeverine is an antispasmodic agent. Mebeverine acid is a valuable marker of oral exposure to Mebeverine.
    Mebeverine acid
  • HY-136611
    ω-Hydroxy-DEET
    		98.60%
    ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes.
    ω-Hydroxy-DEET
  • HY-133980
    O-Demethyl Lenvatinib
    O-Demethyl Lenvatinib is a metabolite of Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities.
    O-Demethyl Lenvatinib
  • HY-125691
    LY-338979
    		99.67%
    LY-338979 (Pemetrexed 6-oxo diacid impurity) is a metabolite of LY231514 (Pemetrexed; HY-10820).
    LY-338979
  • HY-135377
    Atorvastatin 3-Deoxyhept-2E-Enoic Acid
    		≥98.0%
    Atorvastatin 3-Deoxyhept-2E-Enoic Acid ((2E)-2,3-Dehydroxy Atorvastatin) is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.
    Atorvastatin 3-Deoxyhept-2E-Enoic Acid
  • HY-137912
    trans-Resveratrol-3-O-β-D-Glucuronide
    trans-Resveratrol-3-O-β-D-Glucuronide is an active metabolite of trans-resveratrol. trans-Resveratrol-3-O-β-D-Glucuronide reduces the proliferation of several intestinal cancer cell line. trans-Resveratrol-3-O-β-D-Glucuronide increases pyruvate production in livers.
    trans-Resveratrol-3-O-β-D-Glucuronide
  • HY-113083
    Acetaminophen glucuronide
    		≥99.0%
    Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005). Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
    Acetaminophen glucuronide
  • HY-138813
    N-Desethyl Sunitinib hydrochloride
    		99.14%
    N-Desethyl Sunitinib (SU-12662) (hydrochloride) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively.
    N-Desethyl Sunitinib hydrochloride
  • HY-133771AS
    Nordoxepin-d3 hydrochloride
    		99.92%
    Nordoxepin-d3 (hydrochloride) is the deuterium labeled Nordoxepin hydrochloride. Nordoxepin hydrochloride is an active metabolite of Doxepin hydrochloride (HY-B0725), which is an orally active tricyclic antidepressant.
    Nordoxepin-d<sub>3</sub> hydrochloride
  • HY-N11424
    Bilirubin diglucuronide
    Bilirubin diglucuronide is the metabolite of Bilirubin (HY-N0323). Bilirubin diglucuronide inhibits MRP1/2 mediated ATP-dependent transport of leukotriene C4 (LTC4) in membrane vesicles.
    Bilirubin diglucuronide
  • HY-W001080R
    3,4-Dihydroxybenzeneacetic acid (Standard)
    3,4-Dihydroxybenzeneacetic acid (Standard) is the analytical standard of 3,4-Dihydroxybenzeneacetic acid. This product is intended for research and analytical applications. 3,4-Dihydroxybenzeneacetic acid is the main neuronal metabolite of dopamine.
    3,4-Dihydroxybenzeneacetic acid (Standard)
  • HY-100662
    Didesethyl chloroquine
    		99.91%
    Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant.
    Didesethyl chloroquine
  • HY-116831
    4′-Dihydrophaseic acid
    		98.70%
    4′-Dihydrophaseic acid is an abscisic-acid metabolite.
    4′-Dihydrophaseic acid
  • HY-137316
    Phosphoramide mustard
    Phosphoramide mustard is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard induces DNA damage.
    Phosphoramide mustard
  • HY-W011245
    Ranitidine S-oxide
    		99.03%
    Ranitidine S-oxide is the metabolite of Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion.
    Ranitidine S-oxide
  • HY-12771
    O-desmethyl Mebeverine acid
    		≥99.0%
    O-desmethyl Mebeverine acid is a metabolite of Mebeverine, which is a musculotropic antispasmodic drug.
    O-desmethyl Mebeverine acid
  • HY-12784
    Cycloguanil
    Cycloguanil, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
    Cycloguanil
Cat. No. Product Name / Synonyms Application Reactivity