2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-138253S
    2′,2′-Difluorodeoxyuridine-13C,15N2
    		99.50%
    2′,2′-Difluorodeoxyuridine-13C,15N2 (dFdU-13C,15N2) is a 13C- and 15N-labeled compound. 2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces apoptosis in cancer cells.
    2′,2′-Difluorodeoxyuridine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-131492
    Δ4-Dafachronic acid
    Δ4-Dafachronic acid is an agonist of DAF-12 and a metabolite of cholesterol.
    Δ4-Dafachronic acid
  • HY-W576312
    N,N-Dimethyltryptamine N-oxide
    		99.8%
    N,N-Dimethyltryptamine N-oxide is a metabolite of N,N-Dimethyltryptamine.
    N,N-Dimethyltryptamine N-oxide
  • HY-129697
    3-Hydroxy Medetomidine
    		≥98.0%
    3-Hydroxy Medetomidine (3-OH Medetomidine; Medetomidine metabolite MIII) is a metabolite of the α2-adrenergic receptor agonist medetomidine.
    3-Hydroxy Medetomidine
  • HY-136498A
    T-705RMP ammonium
    T-705RMP (ammonium) is the ammonium form of T-705RMP. T-705RMP (ammonium)’s the inhibition of IMP dehydrogenase (IMPDH) activity is weak .
    T-705RMP ammonium
  • HY-B1103
    Hydroxyhexamide
    		99.60%
    Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents.
    Hydroxyhexamide
  • HY-116909
    O-Methylsterigmatocystin
    		99.3%
    O-Methylsterigmatocystin is a metabolite in Aspergillus flavus and Aspergillus parasiticus.
    O-Methylsterigmatocystin
  • HY-171459
    LEQ803
    		98.04%
    LEQ803 (N-Desmethyl Ribociclib) is a drug metabolite of the CDK4/6 inhibitor Ribociclib (HY-15777), which is produced through metabolism by CYP3A4. LEQ803 has potential application value in the field of oncology.
    LEQ803
  • HY-G0004
    Acetaminophen metabolite 3-hydroxy-acetaminophen
    		99.76%
    Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) is a non-toxic metabolite and antioxidant of acetaminophen (HY-66005) with free radical scavenging activity. Acetaminophen metabolite 3-hydroxy-acetaminophen can reduce oxidative damage by exerting electron donation ability and antioxidant activity through phenolic hydroxyl groups. 3-hydroxy-acetaminophen can be used to study the toxicity mechanism and drug metabolism of acetaminophen.
    Acetaminophen metabolite 3-hydroxy-acetaminophen
  • HY-126857S
    5-Hydroxy Omeprazole-d3
    		98.27%
    5-Hydroxy Omeprazole-d3 is deuterium labeled 5-Hydroxyomeprazole.
    5-Hydroxy Omeprazole-d<sub>3</sub>
  • HY-17528
    Cyhalofop
    Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture.
    Cyhalofop
  • HY-W338852
    Gentisuric acid
    		99.65%
    Gentisuric acid, a metabolite of Aspirin (HY-14654), is a substrate of α-amidating monooxygenase (PAM). Gentisuric acid prevents DNA-damage by Mitomycin C (HY-13316).
    Gentisuric acid
  • HY-W747072
    3-Sulfo-taurocholic Acid Disodium Salt
    		≥99.0%
    3-Sulfo-taurocholic Acid Disodium Salt (3-Sulfocholyl Taurine; TCA3S) is a metabolite of the conjugated bile acid taurocholic acid. Plasma levels of 3-Sulfo-taurocholic Acid Disodium Salt are elevated in wild-type and Sortilin 1 (Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated in Sort1 knockout mice at 24 hours post-BDL.
    3-Sulfo-taurocholic Acid Disodium Salt
  • HY-W588187
    Coprostanone
    		98.25%
    Coprostanone (5β-cholestan-3-one) is an oxysterol and active metabolite of Cholesterol (HY-N0322). Coprostanone induces apoptosis in primary dog gallbladder epithelial cells. Coprostanone is promising for research of colon cancers or adenomatous polyps.
    Coprostanone
  • HY-77101
    AP24592
    		99.18%
    AP24592 (M19) is an aromatic amine.
    AP24592
  • HY-I0169
    (R)-Amino-N-benzyl-3-methoxypropionamide
    		99.95%
    (R)-Amino-N-benzyl-3-methoxypropionamide is a stable intermediate of Lacosamide (an antiepileptic drug).
    (R)-Amino-N-benzyl-3-methoxypropionamide
  • HY-130189R
    S-Phenylmercapturic acid (Standard)
    S-Phenylmercapturic acid (Standard) is the analytical standard of S-Phenylmercapturic acid. This product is intended for research and analytical applications. S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay.
    S-Phenylmercapturic acid (Standard)
  • HY-W037282
    O-Desmethyl quinidine
    		99.05%
    O-Desmethyl quinidine (Cupreidine) is an orally active metabolite of Quinine (HY-D0143). O-Desmethyl quinidine reduces frequency of cramps in rats with spinal cord injury and shows low blood toxicity.
    O-Desmethyl quinidine
  • HY-145453
    Propacetamol
    		Control 98.38%
    Propacetamol is an analgesic agent. Propacetamol also is a precursor form of paracetamol. Propacetamol can be used in postoperative pain, acute trauma and gastrointestinal disorders.
    Propacetamol
  • HY-126303
    GS-443902
    		99.87%
    GS-443902 (GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir.
    GS-443902
Cat. No. Product Name / Synonyms Application Reactivity